Adhesion in Leukocyte Homing and Differentiation by F. Melchers (auth.), Dominique Dunon Ph.D., Charles R.

By F. Melchers (auth.), Dominique Dunon Ph.D., Charles R. Mackay Ph.D., Beat A. Imhof Ph.D. (eds.)

This quantity of present subject matters in Microbiology and Immunology used to be deliberate in parallel with an EM BO workshop on cell-cell Interactions in Leukocyte Homing and Differentiation held on the Basel Institute for Immunology in November 1992, and plenty of of the workshop audio system have contributed to it. telephone adhesion is without doubt one of the so much dynamic fields of organic examine and provided during this e-book is the present wisdom at the constitution and serve as of the most important households of mobilephone adhesion molecules-the integrins, the selectins, the immunoglobulin superfamily, and CD44. advanced interactions among the contributors of those households mediate diversified adhesion capabilities, together with leukocyte-leukocyte interactions, lymphocyte homing, irritation, and lymphocyte-stromal cellphone interplay in the course of hematopoiesis. loads of emphasis is put on the regulatory parts that keep watch over the expression and serve as of adhesion molecules. Cytokines not just set off the expression of definite adhesion molecules, yet can also regulate their useful prestige. for example, the integrins exist in both an inactive nonfunctional shape or an energetic sensible shape, and a couple of intracellular or extracellular stimuli adjust integrin functionality. this can be really vital in the course of leukocyte binding to endothelium and transendothelial migration, which proceeds via a cascade of adhesion occasions. even though telephone adhesion molecules play a huge position in lots of procedures, this ebook concentrates on their position in the immune procedure. a few chapters talk about the migration of lymphocytes among hematopoietic organs similar to the thymus, lymph nodes, Peyer's patches, and spleen.

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J Cell Bioi 115: 257-266 34 A. Sonnenberg Tamkun JW, DeSimone DW, Fonda D, Patel RS, Buck C, Horwitz AF, Hynes RO (1986) Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell 46: 271-282 Tamura R, Rozzo C, Starr L, Chambers J, Reichardt LF, Cooper HM, Quaranta V (1990) Epithelial integrin rx6{34: complete primary structure of rx6 and variant forms of {34' J Cell Bioi 111: 1 593-1604 Tamura RN, Cooper H M, Collo G, Quaranta V (1991) Specific integrin variants with alternative rx chain cytoplasmic domains.

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184 © Springer-Verlag Berlin . M. DeLisser et al. endothelial cells (endoCAM) that was also present on platelets and leukocytes. Antibodies against endoCAM were able to prevent initial endothelial cell-cell contacts (ALBELDA et al. 1990). In 1990, NEWMAN et al. reported the molecular cloning of a 130 kDa cell surface protein, designated PECAM-1 (platelet endothelial cell adhesion molecule-1), common to both platelets and endothelial cells (NEWMAN et al. 1990). When it was found that antibodies directed against the hec7 antigen, endoCAM, and one of the previously identified myelomonocytic antigens (SG134) reacted with PECAM-1, it became evident that PECAM-1 was identical to the CD31 antigen.

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