Anti-Idiotypes, Receptors, and Molecular Mimicry by D. Scott Linthicum, Nadir R. Farid

By D. Scott Linthicum, Nadir R. Farid

Here is an up to date evaluation of vital new tools and leads to anti-idiotypes, receptors, and molecular mimicry.It starts off with a dialogue of the theoretical historical past ofthe anti-idiotypic community, it truly is function within the legislation of immune reaction, and the actual features of anti-idiotypic antibodies. It then is going directly to discover many exciting purposes in such parts as insulin motion, thyroid cellphone functionality, the neurosciences, cardiology, virology, pharmacology, and replica.

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VIII. The response of CBAIN mice to PC-LPS. J. Immunol. 126: 1790. , J. A. Cazenave. 1982. Recurrent idiotypes and internal images. EMBO J. 1:243. 4 Anti-Idiotypes as Probes of Immunoglobulin Structure ROBERT L. RAISON AND ALLEN B. EDMUNDSON Introduction Idiotypes, which represent antigenic determinants located in immunoglobulin (lg) variable regions, may be used as probes of antibody combining sites. These determinants range from those shared by other immunoglobulins exhibiting similar ligand binding properties to private idiotopes expressed only on the original immunogen.

However, there are other potential uses for complementary peptides which have not yet been discussed. From a diagnostic point of view, peptides which are relatively small with high binding affinity for a specific ligand would be advantageous in clinical assay procedures. Presently, radioimmunoassays and ELISA procedures depend upon the production of a specific, high-affinity antibody. In many cases, these antibodies are costly to make, there can be significant differences between different lots of antibodies, and the antibodies sometimes have limiting shelf lives.

B. , unpublished work). After prolonged incubation with hapten, the complex was dialyzed to remove bis(DNP)lysine from the main cavity. The ligand in the deep pocket remained firmly bound. 0 mole of bis(DNP)lysine per mole of Mcg dimer, as determined by absorbance at 365 nm. This preparation showed a markedly reduced ability to bind the M3. 9 antibody, as indicated by low inhibition levels obtained in the assay (Fig. 6). The above effect was not due to loss of the idiotope on the noncovalent form of the Mcg dimer since the inhibition curve obtained with a nonliganded control was identical to that obtained with the covalent dimer (Fig.

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